Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents.
نویسندگان
چکیده
Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.
منابع مشابه
EVALUATION OF ANTIOXIDANT AND ANTIFUNGAL PROPERTIES OF NEW DERIVATIVES OF PERAZOLO [3,4-D]PYRIMIDINE
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In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuranchalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structuresof title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analyticaland spectral data. The synthesized compounds were screened for antimicrobial activityand molecular docking studies. Some ...
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ورودعنوان ژورنال:
- European journal of medicinal chemistry
دوره 45 2 شماره
صفحات -
تاریخ انتشار 2010